I don't disagree with you - American pharmaceuticals in particular still seem weirdly gung-ho about excluding female participants from studies. Coming from Europe we routinely have to tell them they're not allowed to do that. ... but I think it's bad faith to say that bad study design makes my point moot, especially when it takes only a few seconds of Googling to find plenty of papers discussing sex-linked effects on drugs/medicinal products. Heck, here's a literature review of sex-linked effects on the pharmakinetics and pharmacodynamics of various drugs, which even acknowledges the bias towards males in various clinical trials you referred to. I don't think the paper mentions it, but I imagine throwing intersex people into the mix would render even more related differences. Which is why your assigned sex at birth matters medically, and I think it is dangerous to conflate it with gender identity (which again is your's to express as you please)